IDENTIFICATION OF WEAK POINTS PRONE FOR MUTATION IN FERREDOXIN OF TRICHOMONAS VAGINALIS
نویسندگان
چکیده
منابع مشابه
Identification of weak points prone for mutation in ferredoxin of Trichomonas vaginalis.
Trichomonas vaginalis, the causative agent for human trichomoniasis, is a problematic sexually transmitted disease mainly in women. At present, metronidazole-resistant trichomoniasis is an infrequent but challenging problem with no universally successful treatment. Genetic mutation is believed to be an important factor leading to increasing drug resistance. Understanding the mutation status wil...
متن کاملFerredoxin Gene Mutation in Iranian Trichomonas vaginalis Isolates
BACKGROUND Trichomonas vaginalis causes trichomoniasis and metronidazole is its chosen drug for treatment. Ferredoxin has role in electron transport and carbohydrate metabolism and the conversion of an inactive form of metronidazole (CO) to its active form (CPR). Ferredoxin gene mutations reduce gene expression and increase its resistance to metronidazole. In this study, the frequency of ferred...
متن کاملferredoxin gene mutation in iranian trichomonas vaginalis isolates.
background: trichomonas vaginalis causes trichomoniasis and metronidazole is its chosen drug for treatment. ferredoxin has role in electron transport and carbohydrate metabolism and the conversion of an inactive form of metronidazole (co) to its active form (cpr). ferredoxin gene mutations reduce gene expression and increase its resistance to metronidazole. in this study, the frequency of ferre...
متن کاملIdentification of Antigenic Proteins in Trichomonas vaginalis
Trichomoniasis is a sexually transmitted disease due to infection with Trichomonas vaginalis, and it can cause serious consequences for women's health. To study the virulence factors of this pathogen, T. vaginalis surface proteins were investigated using polyclonal antibodies specific to the membrane fractions of T. vaginalis. The T. vaginalis expression library was constructed by cloning the c...
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Abstract Background and Objective: Trichomonas vaginalis is a pathogenic agent known worldwide and affects about 180 million annually. We aimed to investigate the prevalence of Trichomonas vaginalis in diabetic patients referred to diabetic research center. Material and Methods: In this descriptive-analytic study, 215 women referring to the Diabetic Center in Kermanshah Province were invest...
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ژورنال
عنوان ژورنال: Indian Journal of Medical Microbiology
سال: 2008
ISSN: 0255-0857
DOI: 10.1016/s0255-0857(21)01934-4